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Targeting NAD+ Salvage Pathway as a Potential Approach to Combat Obesity
2024年3月15日
肥満と闘うための潜在的なアプローチとしてのNAD +サルベージ経路をターゲットにする
Introduction Mar 4th is determined as the World Obesity Day. World Obesity Federation, UNICEF and WHO have hosted a global youth-led webinar to talk about obesity & youth. The obesity crisis has gradually attr
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Tailoring Personalized Dosage Regimens of NMN Based on NAD Concentration
2024年3月13日
NAD濃度に基づくNMNの個別投与計画の調整
Introduction Nicotinamide mononucleotide (NMN), one precursor of nicotinamide adenine dinucleotide (NAD+), has been ascertained to be implicated with multiple biological processes such as cellular redox regulation and
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NR as a Promising Therapeutic Candidate for Alpers' Disease
2024年3月12日
アルパース病の有望な治療薬候補としてのNR
Introduction Alpers' disease is both a neurodegenerative disorder and a metabolic disorder, which is tightly linked to mitochondrial dysfunction and mutations in the catalytic subunit of polymerase
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Deep Insight on NADH: a Potential Medical Arsenal
2024年3月11日
NADHに関する深い洞察:潜在的な医療兵器
  Introduction NADH (reduced form of NAD+) serves as a carrier of biological hydrogen and an electron donor, which participates in diverse physiological processes such as protein synthesis, DNA repair,
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Frontier Dynamics on the Molecular Mechanism of Ginsenoside Rh2 Against Tumor
2024年3月7日
腫瘍に対するジンセノサイドRh2の分子機構に関するフロンティアダイナミクス
  Introduction Ginsenoside Rh2, one protopanaxadiol (PPD)-type rare ginsenoside in Panax ginseng, is uncovered to possibly have broad-spectrum pharmacological activity in diversified tumors. It is utili
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SLC25A51 Functions as an NAD+/NADH Redox Decoupler in AML
2024年3月5日
SLC25A51 AMLにおけるNAD+/NADHレドックスデカプラーとして機能
Introduction Solute carrier family 25 member 51 (SLC25A51) is perceived as a mammalian transporter, which is capable of importing oxidized nicotinamide adenine dinucleotide (NAD+) into mitochondrial matrix. Remark
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The Molecular Mechanisms Underlying the Interaction Between NAD+/NMN and DBC1
2024年3月4日
NAD+/NMNとDBC1の相互作用の分子機構
Introduction Oxidized form of nicotinamide adenine dinucleotide (NAD+) and its precursor nicotinamide mononucleotide (NMN) have been uncovered to restore DNA repair and prevent cancer progression via the deleted i
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Protective Role of NAD+ Against MI-induced HF in Sprague-Dawley Rats and Beagles
2024年2月29日
Sprague-Dawleyラットおよびビーグル犬におけるMI誘発性HFに対するNAD +の保護的役割
1. Introduction Disrupted nicotinamide adenine dinucleotide (NAD+) metabolism is increasingly deemed to be one of risk factor for amendable cardiovascular disorders. A substantial evidence has mirrored that res
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Investigating the Great Possibility of Rare Ginsenosides as Drugs and Nutraceuticals
2024年2月28日
医薬品や栄養補助食品としての希少なジンセノサイドの大きな可能性を調査
1. Introduction Rare ginsenosides, a group of dammarane triterpenoids that exist in low natural abundance, fuels a high concern from scholars recently, showing great potential as shining components in drugs and nu
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